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Following is a breakdown of the benefits and risks of TRT compared with the many risks of anabolic steroid use for bodybuildingathletes. Benefits In an animal model, testosterone produced in the testes was found to induce weight loss: "Ingested testosterone has significantly diminished adipose tissue mass and adipocyte size, decreased body fat, increased skeletal muscle mass, lowered triglyceride, and increased muscle protein synthesis. In healthy men, supplementation with testosterone resulted in a loss of fat mass of approximately 0.75 kg while a weight loss of approximately 1.0 kg was observed on the basis of the initial body composition of the subjects. Although testosterone therapy in overweight and obese humans may be beneficial, it remains to be determined whether this is an effective strategy to achieve fat loss in humans. Future clinical trials are necessary to evaluate the efficacy and safety of testosterone therapy in overweight and obese subjects." In one study, the administration of TRT by itself significantly reduced fat mass and body fat over 6 months in over 4,000 people, suggesting these long-term effects are not due to the TRT itself: "Fat mass and skinfold thickness are decreased more frequently with weight loss, and body fat mass is typically increased following weight loss. Both of these changes are more pronounced with increased body fat mass. In order to minimize the potential for adverse side effects with testosterone therapy, we administered testosterone gel containing either testosterone esters or a combination of testosterone enanthate and levonorgestrel, the most commonly used long-acting androgen replacement and/or androgen in the United States." Another study found that testosterone gel did not affect blood pressure. When participants went on to take a placebo pill after the study, they had a slight increase in blood pressure as expected, but if the study was followed up 6 months later, testosterone gel significantly decreased blood pressure. A study in the journal International Journal of Obesity reported that testosterone therapy can reduce fat mass while not affecting testosterone levels in younger males. However, the data is inconclusive due to a small sample size, which means they cannot draw conclusions on how TRT compares with testosterone therapy in obese males. Studies from elsewhere show that there can be a large benefit of testosterone therapy in people with an underweight BMI (BMI < 18.5) whose testosterone levels are already in the normal range. In many cases, the benefits are very similar to the benefits of testosterone therapy for people with otherwise elevated testosterone levels (ie. those who already have been on TRT for awhile). Risks TRT does not appear to have an equal or greater risk of Similar articles: